Symbol
Name
ID

Rr253
regulatory region 253
MGI:7331605

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

abnormal class switch recombination

increased neutrophil cell number

decreased plasmacytoid dendritic cell number

decreased dendritic cell number

increased dendritic cell number

decreased B cell number

decreased mature NK cell number

increased NK cell number

abnormal effector T cell number

increased T cell number

increased lymphocyte cell number

decreased monocyte cell number

abnormal peritoneal macrophage morphology

spleen hypoplasia

abnormal spleen B cell follicle morphology

decreased spleen B cell follicle number

decreased spleen B cell follicle size

abnormal T-helper 2 physiology

increased susceptibility to parasitic infection induced morbidity/mortality

increased susceptibility to viral infection induced morbidity/mortality

Availability

Mouse Genotype

Rr253^em1Kmm/Rr253^em1Kmm

Rr253^em3Kmm/Rr253^em3Kmm

Rr253^em4Kmm/Rr253^em4Kmm

Rr253^em5Kmm/Rr253^em5Kmm

Rr253^em6Kmm/Rr253^em6Kmm

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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